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Xiaokun Li Selected Research

Insulin (Novolin)

1/2021Dynamic folding modulation generates FGF21 variant against diabetes.
11/2020Curtailing FGF19's mitogenicity by suppressing its receptor dimerization ability.
1/2019Pancreatic fibroblast growth factor 21 protects against type 2 diabetes in mice by promoting insulin expression and secretion in a PI3K/Akt signaling-dependent manner.
1/2018FGF21 and DPP-4 inhibitor equally prevents cognitive decline in obese rats.
1/2018Fibroblast growth factor 1 ameliorates diabetic nephropathy by an anti-inflammatory mechanism.
3/2017Fibroblast growth factor-21 restores insulin sensitivity but induces aberrant bone microstructure in obese insulin-resistant rats.
1/2016FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats.
5/2013Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice.
2/2011Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo.
12/2010Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile.

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Xiaokun Li Research Topics

Disease

66Neoplasms (Cancer)
04/2024 - 10/2007
50Inflammation (Inflammations)
04/2024 - 12/2009
35Wounds and Injuries (Trauma)
04/2024 - 03/2005
25Fibrosis (Cirrhosis)
04/2024 - 11/2008
25Obesity
12/2023 - 01/2012
23Insulin Resistance
01/2023 - 02/2011
16Type 2 Diabetes Mellitus (MODY)
01/2024 - 01/2012
16Hyperglycemia
01/2023 - 10/2006
13Diabetic Nephropathies (Diabetic Nephropathy)
01/2023 - 04/2007
12Diabetic Cardiomyopathies
04/2024 - 10/2006
12Spinal Cord Injuries (Spinal Cord Injury)
01/2024 - 05/2014
12Infections
07/2023 - 02/2014
12Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2018 - 12/2009
10Hypertrophy
04/2024 - 07/2010
10Cognitive Dysfunction
07/2021 - 04/2006
9Body Weight (Weight, Body)
02/2023 - 01/2012
8Hypoxia (Hypoxemia)
04/2024 - 06/2012
8Metabolic Diseases (Metabolic Disease)
06/2023 - 02/2010
8Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2020 - 09/2012
8Schizophrenia (Dementia Praecox)
05/2014 - 12/2005
7Esophageal Squamous Cell Carcinoma
05/2024 - 01/2020
7Diabetes Complications
04/2024 - 07/2007
7Neoplasm Metastasis (Metastasis)
12/2023 - 12/2014
7Hyperlipidemias (Hyperlipidemia)
01/2023 - 01/2009
7Fatty Liver
01/2023 - 08/2015
7COVID-19
11/2021 - 01/2020
7Carcinogenesis
11/2019 - 07/2010
6Lung Neoplasms (Lung Cancer)
01/2024 - 06/2011
6Hepatocellular Carcinoma (Hepatoma)
12/2023 - 05/2010
6Reperfusion Injury
07/2023 - 04/2007
6Ischemia
01/2023 - 04/2007
6Non-alcoholic Fatty Liver Disease
01/2023 - 01/2012
6Necrosis
01/2022 - 10/2014
6Diabetes Mellitus
01/2019 - 04/2011
6Cardiovascular Diseases (Cardiovascular Disease)
02/2018 - 11/2014
5Esophageal Neoplasms (Esophageal Cancer)
03/2024 - 01/2022
5Prostatic Neoplasms (Prostate Cancer)
10/2023 - 04/2010
5Cardiomegaly (Heart Hypertrophy)
01/2023 - 01/2016
5Brain Ischemia (Cerebral Ischemia)
07/2022 - 10/2017
5Cicatrix (Scar)
01/2022 - 01/2008
5Heart Diseases (Heart Disease)
07/2021 - 01/2013
5Mitochondrial Diseases (Mitochondrial Disease)
01/2018 - 10/2014
4Hypertension (High Blood Pressure)
12/2023 - 01/2009
4Ischemic Stroke
12/2023 - 01/2008
4Colorectal Neoplasms (Colorectal Cancer)
11/2023 - 10/2017
4Acute Lung Injury
04/2023 - 03/2016

Drug/Important Bio-Agent (IBA)

57fibroblast growth factor 21IBA
04/2024 - 02/2010
47Proteins (Proteins, Gene)FDA Link
04/2024 - 04/2006
22Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
10/2023 - 07/2007
22Glucose (Dextrose)FDA LinkGeneric
02/2023 - 02/2011
21Fibroblast Growth Factor 1 (FGF-1)IBA
02/2023 - 04/2007
18Fibroblast Growth Factors (Fibroblast Growth Factor)IBA
04/2024 - 01/2010
18LipidsIBA
12/2023 - 12/2010
17Streptozocin (Streptozotocin)FDA Link
01/2019 - 01/2008
13Phosphotransferases (Kinase)IBA
04/2024 - 01/2010
11HydrogelsIBA
01/2024 - 07/2016
10Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
04/2024 - 10/2013
10Angiotensin IIIBA
12/2023 - 07/2011
10Hormones (Hormone)IBA
12/2023 - 05/2013
10Peptides (Polypeptides)IBA
02/2023 - 05/2009
10Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
11/2022 - 03/2005
10Insulin (Novolin)FDA Link
01/2021 - 12/2010
10Neuroprotective AgentsIBA
01/2021 - 09/2006
9CollagenIBA
04/2024 - 01/2008
9Messenger RNA (mRNA)IBA
12/2022 - 01/2010
9Nerve Growth Factor (NGF)IBA
11/2022 - 05/2014
9Heparin (Liquaemin)FDA LinkGeneric
01/2021 - 01/2016
8LigandsIBA
03/2024 - 08/2011
8Biomarkers (Surrogate Marker)IBA
03/2024 - 05/2014
8Therapeutic UsesIBA
11/2023 - 01/2006
8CurcuminIBA
01/2015 - 03/2009
7CytokinesIBA
12/2023 - 07/2012
7AntioxidantsIBA
01/2023 - 10/2006
6Adenosine Triphosphate (ATP)IBA
01/2024 - 03/2014
6AdiponectinIBA
12/2023 - 04/2011
6AlbuminsIBA
01/2021 - 04/2011
6ErbB Receptors (EGF Receptor)IBA
01/2019 - 03/2016
6Antipsychotic Agents (Antipsychotics)IBA
08/2009 - 01/2006
6Quetiapine Fumarate (Seroquel)FDA Link
08/2009 - 12/2005
5Fibroblast Growth Factor 10IBA
11/2023 - 10/2017
5EnzymesIBA
01/2023 - 01/2010
5Reactive Oxygen Species (Oxygen Radicals)IBA
01/2023 - 07/2012
5Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2022 - 07/2010
5Epidermal Growth Factor (EGF)IBA
11/2022 - 07/2007
5Long Noncoding RNAIBA
09/2021 - 01/2019
5ApolipoproteinsIBA
01/2021 - 12/2010
5Triglycerides (Triacylglycerol)IBA
01/2021 - 12/2010
5Blood Glucose (Blood Sugar)IBA
01/2021 - 12/2010
5Poloxamer (Poloxamer 407)IBA
01/2020 - 03/2017
5Caspase 3 (Caspase-3)IBA
01/2019 - 10/2006
5CreatinineIBA
01/2019 - 04/2011
5MetallothioneinIBA
06/2012 - 10/2006
4Type 1 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 1)IBA
04/2024 - 04/2015
4Brain-Derived Neurotrophic Factor (BDNF)IBA
01/2024 - 01/2006
4Acetates (Acetic Acid Esters)FDA Link
12/2023 - 05/2012
4LipopolysaccharidesIBA
04/2023 - 01/2016
4Retinaldehyde (Retinal)IBA
11/2022 - 04/2007
4Protein Isoforms (Isoforms)IBA
01/2022 - 04/2010

Therapy/Procedure

51Therapeutics
04/2024 - 10/2007
5Neoadjuvant Therapy
05/2024 - 01/2022